Preparing Targets for V(D)J Recombinase: Transcription Paves the Way

Transcription Paves the Way Preparing Targets for V(D)J Recombinase:

Gesture paves the way for language development.

In development, children often use gesture to communicate before they use words. The question is whether these gestures merely precede language development or are fundamentally tied to it. We examined 10 children making the transition from single words to two-word combinations and found that gesture had a tight relation to the children's lexical and syntactic development. First, a great many of...

Auxin Paves the Way for Planar Morphogenesis

The coordinated growth of epidermal cells in plant leaves creates the characteristic jigsaw puzzle appearance of the pavement cells. Now, Xu et al. (2010) report that AUXIN-BINDING PROTEIN 1 mediates auxin activation of two GTPase pathways that antagonistically control planar morphogenesis of leaf epidermal cells to create this distinctive pattern.

Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets

The Food and Drug Administration Adverse Event Reporting System (FAERS) remains the primary source for post-marketing pharmacovigilance. The system is largely un-curated, unstandardized, and lacks a method for linking drugs to the chemical structures of their active ingredients, increasing noise and artefactual trends. To address these problems, we mapped drugs to their ingredients and used nat...

MSF again paves the way with ART.

Médecins Sans Frontières (MSF) has once again paved the way in local HIV/AIDS treatment, this time piloting ART adherence clubs in Khayelitsha outside Cape Town, improving adherence (and thus sustained virological suppression and immunological recovery) over mainstream care by a full 12%.